Among the techniques mentioned above, taste masking by ion exchange resins was selected. Taste masking by formulation of inclusion complexes. Taste masked orodispersible formulation of fexofenadine. Ion exchange resins and applications in pharmaceutical. The taste masking potential of the selected resins was found to increase with increasing concentration of resin in drug resinate. Development of taste masked levofloxacin oral suspension. Complexation with ion exchange resin is a simple, efficient and proven technique for taste masking of a number of bitter tasting drugs 1115. The nature of the drug resin complex formed is such that the average ph of 6. In the present work the drug clarithromycin is a free base for which a weak acid cation exchange resin is useful for taste masking. The use of ion exchange resins to stabilize molecules such as vitamin b122 was discovered early in their history ca1958, but this b12 resinate is still made and sold. Pdf taste masking of ciprofloxacin by ionexchange resin. Development of taste masked liquid formulation of tinidazole. The resins like indion 204, indion 214 and tulsion 335 was tested at various ratios. The excipients used in the formulation was tested by drugexcipients compatibility study which showed no compatibility issues.
Bhatt a, harshad brahmbhatt b, pritpal singh anand a, kiritkumar mangaldas popat a,c, a reverse osmosis membrane division, central salt and marine chemicals research institute. Formulation and evaluation of orodispersible tablet of. Design, optimization and evaluation of chewable tablets of. In beyond few years, ier had been substantially studied within the development of novel drug shipping machine and different biomedical packages. Taste masking occurs because the resinate is insoluble and therefore has no taste.
The drug resin complexes were prepared by batch process using drug. Ion exchange resins have been increasingly used for the taste masking of bitter taste drug and help to prepare orodispersible tablets nandgude et al. Taste masking of ciprofloxacin by ion exchange resin. Ion exchange resins an approach for the development of. There are limited approaches available to improve the taste of nzd by the ionexchange resin method. The selection of an ion exchange resin for a particular drug delivery application is generally based upon its functional group characteristics. Pdf taste masking of nizatidine using ionexchange resins. The present study was carried out in order to mask the bitter taste of the etoricoxib by complexation with cationexchange resin, indion 204. The purpose of this study was to mask the bitter taste of nizatidine nzd using cationexchange resins. For taste masking purpose weak cation exchange or weak anion exchange resins are used, depending on the nature of drug. Taste masking of clarithromycin using complexation with ion exchange resin article pdf available in international journal of pharmtech research 61.
Thus the objective of the present study was to utilize this technique to mask the bitter taste of clarithromycin, using tulsion335 which is a weak acid cation exchange resin. The drug resin complexes drc were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drugresin ratio 1. Pdf ion exchange resins are water insoluble crosslinked polymers containing a saltforming group at repeating positions on the polymer chain. Masking the bitter taste of actives using ion exchange. Some example of this application are shown in table iii. Ion exchange resins iers are high molecular weight polymers with cationic and anionic functional groups most common polymeric network is a copolymer of styrene and. Taste masking of ciprofloxacin by ion exchange resin and sustain release at gastricintestinal through interpenetrating polymer network. Ion exchange resins ier have received vast interest from pharmaceutical scientists because of their versatile residences as drug transport vehicles. According to the ionic nature of the material they are known as cationexchange resins cer or anionexchange resins aer, which can be further classified as strong acid or base and weak acid or base. Introduction ion exchange resins are suitably insoluble high molecular weight polyelectrolyte, which has exchangeable mobile ions, which are. Ion exchange resins are waterinsoluble, crosslinked p olymers containing salt forming groups in repeating positions on. The nature of the drug resin complex formed is such. Present study was aimed at taste masking of ofloxacin using ion exchange resins as a taste masking agents.
Bitter cationic drugs get adsorbed on to weak cationic exchange resins of carboxylic acid functionality like indion 204, indion 234 and tulsion 335 to forms nonbitter complexes. For this study, four different ion exchange resins were exercised and optimized by different ionexchange resin to drug ratio. Ion exchange resin proved a great role in masking of bitter taste. An ionexchange resin or ionexchange polymer is a resin or polymer that acts as a medium for ion exchange.
The use of ionexchange materials that manifest speci. From the different variety of the cation exchange resins available in the market, tulsion, a reputed brand of ion exchange resins of thermax india ltd. There are limited approaches available to improve the taste of nzd by the ion exchange resin method. Ion exchange resin ier method weak cation exchange or weak anion exchange resins are used for taste masking, depending on the nature of drug. Being high molecular weight water insoluble polymers, the resins are not absorbed by the body and are therefore inert 2. Our comprehensive portfolio and extensive technical staff put us in a unique position to create innovative solutions that enable manufacturers to solve the most complex problems facing the. Taste masking by drugresin complexation is achieved when an ionizable drug reacts with a suitable ion exchange resin to form a drugresinate complex nanda and garg, 2002. Pdf taste masking of clarithromycin using complexation. Synthetic ion exchange resins have been used in pharmacy and medicine for taste masking or controlled release of drug as early as 19501. Masking the bitter taste of actives using ion exchange resins is one among the economical methods reported. It is an insoluble matrix or support structure normally in the form of small 0.
Taste masking of nizatidine using ion exchange resins mdpi. Ion exchange resin ier provide alternative method for taste masking. Ier are solid and suitably insoluble high molecular weight poly electrolytes that can exchange their mobile ions of equal charge with the surrounding medium. Finally, the taste masked drug was checked for taste sensation on human volunteer. For taste masking of ofloxacin, ionexchange resin method was used. Synthetic ion exchange resins have been used in pharmacy and medicine for taste. In the product, the resindrug complexes were further coated with a layer containing ethylcellulose and hydroxypropylmethylcellulose for suppression of drug release in saliva. Research paper taste masking of topiramate by newer. Among many taste masking techniques, the formation of a complex with an ion exchange resin is simple and coste. Thus the objective of the present study was to utilize this technique to mask the bitter taste of levofloxacin weakly basic drug, using tulsion335 which is a weak acid cation exchange resin.
Ion exchange resins are solid and suitable in solubilised high molecular weight polyelectrolytes that can exchange their. The invention relates to the formulation of oral liquid products of quinolones or derivatives thereof using ion exchange resins, such as methacrylic acid polymer crosslinked with divinylbenzene, as the carrier, thereby eliminating the extreme bitterness of the quinolones oral liquid formulation. Complexation with ion exchange resin is a simple, efficient and proven technique for taste masking of a number of bitter tasting drugs 1012. Ion exchange resin an overview sciencedirect topics. Taste masking and evaluation of oral disintegrating tablet. Various techniques have been identified for taste masking with cyclodextrin, use of ion exchange resins, solubility limiting, multiple emulsions, use of anesthetic agents, etc. Taste masking of etoricoxib by using ionexchange resin. This invention relates to the formulation of oral liquid products of quinolones or derivatives thereof using ion exchange resins, such as methacrylic acid polymer crosslinked with divinylbenzene, as the carrier, thereby eliminating the extreme bitterness of the quinolones oral liquid formulation. An ideal taste masking process and formulation should have the following properties. Among many tastemasking techniques, the formation of a complex with an ionexchange resin is simple and coste. Us6514492b1 taste masking of oral quinolone liquid.
Some ion exchange resins used widely for amberlite irp69, indion 204, indion 214, kyron t114 and 104. Pdf more than 50% of pharmaceutical products are orally administered for several reasons and undesirable taste is one of the important formulation. Taste mask, design and evaluation of an oral formulation. Taste masking of nizatidine using ionexchange resins.
Ion exchange resins have been widely used as a drug carrier in pharmaceutical dosage forms for their taste masking and controlled release applications11 cefpodoxime proxetil is a third generation cephalosporin antibiotic given orally which is very slightly soluble in. The present investigation aims at taste masking of the bitter clarithromycin using ion exchange resins, which forms complexes. While designing tablet dosage forms, the tongue encounters bitter taste when the active ingredient is released in the mouth. Ion exchange resins have been gradually more used for the taste masking of bitter taste drug and help to prepare oral. The beads are typically porous, providing a large surface area on and inside them the trapping of. The aim of the study was to taste mask ciprofloxacin cp by using ionexchange resins iers followed by sustain release of cp by forming interpenetrating. The sustainedrelease of drug can be obtained by using a mixture of uncoated and semipermeable coated resinates 2326. Taste masking of nizatidine using ion exchange resins. Taste masking of ciprofloxacin by ionexchange resin and sustain. Pdf taste masking by ionexchange resin and its new application.
Taste masking of ciprofloxacin by ionexchange resin and. Ion exchange resins ion exchange resins are synthetic organic polymers inert in nature, consists of a hydrocarbon chain to which insoluble groups are attached, and they have ability to exchange their labile ions for ions present in the solution with which they are in contact. Wo2001005431a1 taste masking of oral quinolone liquid. Amberlite irp69 and dowex50 containing crosslinked polystyrene backbones were used. Ion exchange resins crosslinked waterinsoluble polymer carrying ionizable functional groups have been used as a drug carrier in pharmaceutical dosage form for taste masking and controlled release dosage forms 1722. Ion exchange resins, taste masking, resin drug complex, controlled release, anion exchange, cation exchange, controlled release, resinates. Ion exchange resins have been widely used as a drug carrier in pharmaceutical dosage forms for their taste masking and controlled release applications. In ion exchange resin ier method weak cation exchange or weak anion exchange resins are used for taste masking, depending on the nature of drug. Design and development of rapidly dissolving films. Taste masking of clarithromycin using complexation with. Tastemasking assessment of orally disintegrating tablets. To mask the bitterness of drug various techniques are available, among those taste masking by use of ion exchange resin is most commonly used commercially 6 ion exchange resins iers are used to mask bitter taste of drug. The intersection of tastemasking and vegetarian ingredients is just one example of duponts forwardthinking strategy for navigating todays market.
437 352 888 948 1533 879 1329 1308 1319 578 1136 707 1073 666 535 1238 95 808 471 501 1334 1001 1197 1416 139 55 1189 189 251 1580 687 208 1568 619 1391 902 533 981 665 396 1120 615 182